Neurobiology of Disease Schizophrenia-Like Features in Transgenic Mice Overexpressing Human HO-1 in the Astrocytic Compartment
نویسندگان
چکیده
Wei Song,1 Hillel Zukor,1,2 Shih-Hsiung Lin,1,2 Jacob Hascalovici,1,2 Adrienne Liberman,1 Ayda Tavitian,1,2 Jeannie Mui,4 Hojatollah Vali,4,5 Xin-Kang Tong,3 Sanjeev K. Bhardwaj,6 Lalit K. Srivastava,6 Edith Hamel,2,3 and Hyman M. Schipper1,2 1Lady Davis Institute, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada, 2Department of Neurology and Neurosurgery, McGill University, and 3Laboratory of Cerebrovascular Research, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada, 4Facility for Electron Microscopy Research and 5Department of Anatomy and Cell Biology, Faculty of Medicine, McGill University, Montreal, Quebec H3A 2B2, Canada, and 6Douglas Hospital and Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada
منابع مشابه
Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment.
Delineation of key molecules that act epigenetically to transduce diverse stressors into established patterns of disease would facilitate the advent of preventive and disease-modifying therapeutics for a host of neurological disorders. Herein, we demonstrate that selective overexpression of the stress protein heme oxygenase-1 (HO-1) in astrocytes of novel GFAP.HMOX1 transgenic mice results in s...
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